琥珀酸二乙基己酯在化妝品中常作皮膚調理劑、成膜劑、增塑劑使用。該成分的致痘風險等級參考自Fulton， J. E. Comedogenicity and irritancy of commonly used ingredients in skin care products. J Soc Cosmet Chem 43， 321 - 333 (1989).